Chemotherapeutic tumour targeting using clostridial spores

Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment

Solid tumour accounts for 90% of all cancers. The current treatment approach for most solid tumours is surgery, however it is limited to early stage tumours. Other treatment options such as chemotherapy and radiotherapy are non-selective, thus causing damage to both healthy and cancerous tissue. Past research has focused on understanding tumour cells themselves, and conventional wisdom has aime...

The potential of clostridial spores as therapeutic delivery vehicles in tumour therapy.

Despite substantial investment in prevention, treatment and aftercare, cancer remains a leading cause of death worldwide. More effective and accessible therapies are required. A potential solution is the use of endospore forming Clostridium species, either on their own, or as a tumour delivery vehicle for anti-cancer drugs. This is because intravenously injected spores of these obligate anaerob...

Clostridial Spores in Animal Feeds and Milk

Milk conservation and its organoleptic quality are greatly affected by different microbial contaminants (Table 1). These microorganisms are present either directly on the animal, in the farm environment or on the milking equipment. Industry requirements and country regulations require that the number of bacteria in raw milk be under a specific amount, often of 100 000 bacterial cells ml-1. Rece...

Clostridial Myositis: Evaluation of Normal Equine Skeletal Muscles for the Presence of Clostridial Spores

Dormant clostridial spores are present in healthy skeletal muscle. Inflammatory events caused by a local and/or systemic insult may lead to development of an anaerobic environment suitable for germination of dormant spores in skeletal muscle and consequent clostridial myositis or clostridial myonecrosis. Author’s address: University of Guelph, Ontario Veterinary College, Department of Clinical ...

Tumour Targeting Using Radiolabelled EGF Conjugates